Was Jamestown almost Spanish?

In 1561, the Spanish ship Santa Catalina captained by Antonio Velázquez, was blown off course near the South Carolina coast.  The winds then drove the vessel several hundred miles north.  The ship entered Chesapeake Bay.  The captain convinced, or more likely, seized two native Americans for display back in Spain, and potentially future translators.

One of the captured Virginia natives was Paquiquino, the 17-year old son of the local native leader.  He was brought to Spain and appeared before King Philip II.  He impressed the King and obtained permission to accompany a Catholic mission back to the Chesapeake region of Virginia.

Paquiquino had been converted to Christianity and claimed to want to spread the faith in America. He was baptised "Don Luís de Velasco".

Soon after the ship that brought them from Havana departed, Don Luís left the Jesuits, supposedly to locate his uncle and seek supplies for the mission. He didn’t return, and the Jesuits eventually realize that they had probably been abandoned.   The Jesuits struggled to survive.

Five months later the Indians wiped out the friars’ outpost except for a boy who escaped to tell the story. The Jesuits never returned to Ajacan; they moved their mission to Mexico.